TYK2
Sign in to saveAlso known as IMD35, JTK1, tyrosine kinase 2, Non-receptor tyrosine-protein kinase
protein-coding gene in the species Homo sapiens
Gene data
TYK2- Name
- tyrosine kinase 2
- Type
- protein-coding
- Position
- 10,350,528–10,380,608 (−)
- Aliases
- IMD35, JTK1
- Ensembl
- ENSG00000105397
- RefSeq RNA
- NM_001385197.1, NM_001385198.1, NM_001385199.1, NM_001385200.1, NM_001385201.1
- RefSeq protein
- NP_001372126.1, NP_001372127.1, NP_001372128.1, NP_001372129.1, NP_001372130.1
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
tyrosine kinase 2
- Symbol
- TYK2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:10,350,528-10,380,608
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein TYK2 PDB 3LXN.png
Show 5 more facts
- HomoloGene ID
- 20712
- exact match
- identifiers.org/ncbigene/7297
- genomic end
- 10380572
- genomic start
- 10461209
- cytogenetic location
- 19p13.2
Sources (7)
via Wikidata · CC0