Structure via PubChem · Public domain (PubChem)
dexbrompheniramine
Sign in to saveAlso known as Disomer®, (S)-(+)-brompheniramine, (S)-brompheniramine, (+)-brompheniraminum, d-brompheniramine, D-brompheniramine, Dexbrompheniraminum, Parabromodylamine
Dexbrompheniramine is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine. It was formerly marketed in combination with pseudoephedrine under the name Drixoral in the US and Canada. It is an alkylamine antihistamine.
Chemical data
- Formula
- C16H19BrN2
- Molecular weight
- 319.24 g/mol
- IUPAC name
- (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
- SMILES
- CN(C)CC[C@@H](C1=CC=C(C=C1)Br)C2=CC=CC=N2
- InChIKey
- ZDIGNSYAACHWNL-HNNXBMFYSA-N
- XLogP
- 3.5
- Polar surface area
- 16.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1963
- Admin. routes
- oral
- Indications
- allergic disease
via ChEMBL · EBI
Research
46 papers- Dexbrompheniramine.2006
- Genetic insights into alcohol-associated liver disease: integrative transcriptome-wide analysis identifies novel susceptibility genes.Frontiers in medicine · 2025
- Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine.Experimental lung research · 2008
- Steady-state bioavailability of dexbrompheniramine and pseudoephedrine from a repeat-action combination tablet.Journal of pharmaceutical sciences · 1985
- Allergic conjunctivitis: a survey of new antihistamines.Journal of ocular pharmacology · 1991
via PubMed
Wikidata facts
- Subclass of
- brompheniramine
- Mass
- 318.073161
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₆H₁₉BrN₂
- Commons category
- Dexbrompheniramine
- medical condition treated
- sinusitis
- isomeric SMILES
- CN(C)CC[C@@H](C1=CC=C(C=C1)Br)C2=CC=CC=N2
- canonical SMILES
- CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2
- World Health Organisation international non-proprietary name
- dexbrompheniramine
- subject has role
- H1 antagonist
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- External links
Dexbrompheniramine is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine. It was formerly marketed in combination with pseudoephedrine under the name Drixoral in the US and Canada. It is an alkylamine antihistamine.
Dexbrompheniramine is a first generation antihistamine that reduces the effects of the neurotransmitter histamine in the body: sneezing, itching, watery eyes, and runny nose.
Excerpted from Wikipedia’s “dexbrompheniramine” article, available under the CC BY-SA 4.0 licence.
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via Wikidata sitelinks · CC0