Structure via PubChem · Public domain (PubChem)
esmolol
Sign in to saveAlso known as (±)-esmolol, (±)-methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate, methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate, 3-[4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl ester, methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate
Esmolol, sold under the brand name Brevibloc, is a cardio selective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages.
Chemical data
- Formula
- C16H25NO4
- Molecular weight
- 295.37 g/mol
- IUPAC name
- methyl 3-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]propanoate
- SMILES
- CC(C)NCC(COC1=CC=C(C=C1)CCC(=O)OC)O
- InChIKey
- AQNDDEOPVVGCPG-UHFFFAOYSA-N
- XLogP
- 1.9
- Polar surface area
- 67.8 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
1,743 papers- Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial.JAMA · 2013
- Esmolol, Antinociception, and Its Potential Opioid-Sparing Role in Routine Anesthesia Care.Regional anesthesia and pain medicine · 2018
- Esmolol.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 1991
- Esmolol in the management of pre-hospital refractory ventricular fibrillation: A systematic review and meta-analysis.The American journal of emergency medicine · 2020
- BET 1: Esmolol-a novel adjunct to the ACLS algorithm?Emergency medicine journal : EMJ · 2020
via PubMed
Wikidata facts
- Mass
- 295.178
Show 4 more facts
- chemical formula
- C₁₆H₂₅NO₄
- canonical SMILES
- CC(C)NCC(COC1=CC=C(C=C1)CCC(=O)OC)O
- Commons category
- Esmolol
- defined daily dose
- 2.5
via Wikidata · CC0
~4 min read
Article
6 sectionsContents
- Medical uses
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- References
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 412885041 | image = Esmolol structure.svg | image_class = skin-invert-image
| tradename = Brevibloc | Drugs.com = | pregnancy_AU = C | pregnancy_category = | routes_of_administration = Intravenous | ATC_prefix = C07 | ATC_suffix = AB09