Structure via PubChem · Public domain (PubChem)
felodipine
Sign in to saveAlso known as 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester, 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate, (+-)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Felodipine is a medication of the calcium channel blocker type that is used to treat high blood pressure.
In the Vinony graph
Vinony's link graph records 578 inbound references to felodipine, and connects out to valproic acid, Hypericum perforatum and amlodipine.
It is catalogued under topics including Antimineralocorticoids, Calcium channel blockers and Carboxylate esters.
Vinony links it to 22 Wikipedia language editions.
Chemical data
- Formula
- C18H19Cl2NO4
- Molecular weight
- 384.2 g/mol
- IUPAC name
- 5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- SMILES
- CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
- InChIKey
- RZTAMFZIAATZDJ-UHFFFAOYSA-N
- XLogP
- 3.9
- Polar surface area
- 64.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
1,834 papers- Felodipine clinical pharmacokinetics.Clinical pharmacokinetics · 1991
- Felodipine in hypertension--a review.Journal of cardiovascular pharmacology · 1987
- Pharmacodynamic properties of felodipine.Drugs · 1987
- Felodipine: a new dihydropyridine calcium-channel antagonist.DICP : the annals of pharmacotherapy · 1991
- The safety of felodipine.Journal of cardiovascular pharmacology · 1990
via PubMed
Wikidata facts
- Mass
- 383.069113
Show 5 more facts
- chemical formula
- C₁₈H₁₉Cl₂NO₄
- defined daily dose
- 5
- canonical SMILES
- CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
- World Health Organisation international non-proprietary name
- felodipine
- Commons category
- Felodipine
Sources (7)
via Wikidata · CC0
~5 min read
Encyclopedic overview
8 sectionsContents
- Medical uses
- Adverse effects
- Interactions
- Mechanism of action
- Chemistry
- History
- Society and culture
- References
Felodipine is a medication of the calcium channel blocker type that is used to treat high blood pressure.
It was patented in 1978, and approved for medical use in 1988.
Excerpted from Wikipedia’s “felodipine” article, available under the CC BY-SA 4.0 licence.