IBSP

Also known as BNSP, BSP, BSP-II, SP-II, integrin binding sialoprotein

protein-coding gene in the species Homo sapiens

Gene data

IBSP

Name: integrin binding sialoprotein
Type: protein-coding
Aliases: BNSP, BSP, BSP II, BSP-II, SP-II

The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008].

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