IGF2

Also known as C11orf43, GRDF, IGF-II, PP9974, insulin like growth factor 2, SRS3, Insulin-like growth factor 2, multiplication-stimulating polypeptide

protein-coding gene in the species Homo sapiens

Gene data

IGF2

Name: insulin like growth factor 2
Type: protein-coding
Position: 2,129,112–2,158,391 (−)
Aliases: C11orf43, GRDF, IGF-II, PP9974, SRS3
Ensembl: ENSG00000167244
RefSeq RNA: NM_000612.6, NM_001007139.6, NM_001127598.3, NM_001291861.3, NM_001291862.3
RefSeq protein: NP_000603.1, NP_001007140.2, NP_001121070.1, NP_001278790.1, NP_001278791.1

This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].