integrin subunit alpha 1
Sign in to saveAlso known as Very Late Antigen-1, laminin and collagen receptor, very late activation protein 1, VLA-1, ITGA1, integrin alpha-1, CD49 antigen-like family member A, Integrin alpha1
mammalian protein found in Homo sapiens
Protein · UniProt
Integrin alpha-1
- Gene
- ITGA1
- Organism
- Homo sapiens (Human)
- Length
- 1,179 aa
- Molecular mass
- 130,848 Da
- Evidence
- 1: Evidence at protein level
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth
3D-structureCalciumCell adhesionDisulfide bondGlycoproteinIntegrinMagnesiumMembrane
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
3,685 papers- Influence of the integrin alpha-1 subunit and its relationship with high-fat diet upon extracellular matrix synthesis in skeletal muscle and tendon.Cell and tissue research · 2020
- Analysis of Integrin α(IIb) Subunit Dynamics Reveals Long-Range Effects of Missense Mutations on Calf Domains.International journal of molecular sciences · 2022
- Interactions via α(2)β(1) Cell Integrin May Protect against the Progression of Airway Structural Changes in Asthma.International journal of molecular sciences · 2021
- Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor.Cell · 1995
- Integrin alpha(3)-subunit expression modulates alveolar epithelial cell monolayer formation.American journal of physiology. Lung cellular and molecular physiology · 2000
via PubMed
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- Commons category
- Integrin alpha-1
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Connections
Q180686
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Ensembl genome database project
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CD1
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protein
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International Standard Book Number
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Wikidata
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chromosome
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Wayback Machine
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digital object identifier
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immunology
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bibcode
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human genome
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Q229883
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base pair
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locus
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Medical Subject Headings
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gene expression
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Online Mendelian Inheritance in Man
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Protein Data Bank
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Q22908627
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