integrin subunit alpha 1
Sign in to saveAlso known as Very Late Antigen-1, laminin and collagen receptor, very late activation protein 1, VLA-1, ITGA1, integrin alpha-1, CD49 antigen-like family member A, Integrin alpha1
mammalian protein found in Homo sapiens
Protein · UniProt
Integrin alpha-1
- Gene
- ITGA1
- Organism
- Homo sapiens (Human)
- Length
- 1,179 aa
- Molecular mass
- 130,848 Da
- Evidence
- 1: Evidence at protein level
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth
3D-structureCalciumCell adhesionDisulfide bondGlycoproteinIntegrinMagnesiumMembrane
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
3,685 papers- Influence of the integrin alpha-1 subunit and its relationship with high-fat diet upon extracellular matrix synthesis in skeletal muscle and tendon.Cell and tissue research · 2020
- Analysis of Integrin α(IIb) Subunit Dynamics Reveals Long-Range Effects of Missense Mutations on Calf Domains.International journal of molecular sciences · 2022
- Interactions via α(2)β(1) Cell Integrin May Protect against the Progression of Airway Structural Changes in Asthma.International journal of molecular sciences · 2021
- Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor.Cell · 1995
- Integrin alpha(3)-subunit expression modulates alveolar epithelial cell monolayer formation.American journal of physiology. Lung cellular and molecular physiology · 2000
via PubMed
Wikidata facts
- Instance of
- antigen
Show 3 more facts
- cell component
- extracellular exosome
- found in taxon
- Homo sapiens
- Commons category
- Integrin alpha-1
Sources (3)
via Wikidata · CC0