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melevodopa
Sign in to saveMelevodopa, also known as levodopa methyl ester (LDME) and sold under the brand name Levomet, is a dopaminergic agent. It is the methyl ester of levodopa. It is used in oral tablet form as an effervescent prodrug with 250times the water solubility of tablet levodopa. In combination with carbidopa, as melevodopa/carbidopa (brand name Sirio), it is approved for use in the treatment of Parkinson's disease.
Research
103 papers- A systematic review on the clinical experience with melevodopa/carbidopa fixed combination in patients with Parkinson disease.Minerva medica · 2019
- Factors associated with motor fluctuations and dyskinesia in Parkinson Disease: potential role of a new melevodopa plus carbidopa formulation (Sirio).Clinical neuropharmacology · 2010
- Liquid melevodopa versus standard levodopa in patients with Parkinson disease and small intestinal bacterial overgrowth.Clinical neuropharmacology · 2014
- Melevodopa/carbidopa effervescent formulation in the treatment of motor fluctuations in advanced Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2010
- Daily motor performance after switching levodopa to melevodopa: an open-label on advanced Parkinson's disease with "delayed-on" and/or"wearing-off".Minerva medica · 2011
via PubMed
Wikidata facts
- Mass
- 211.084
Show 3 more facts
- chemical formula
- C₁₀H₁₃NO₄
- canonical SMILES
- COC(=O)C(CC1=CC(=C(C=C1)O)O)N
- isomeric SMILES
- COC(=O)[C@H](CC1=CC(=C(C=C1)O)O)N
Sources (2)
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Article
2 sectionsContents
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Melevodopa, also known as levodopa methyl ester (LDME) and sold under the brand name Levomet, is a dopaminergic agent. It is the methyl ester of levodopa. It is used in oral tablet form as an effervescent prodrug with 250times the water solubility of tablet levodopa. In combination with carbidopa, as melevodopa/carbidopa (brand name Sirio), it is approved for use in the treatment of Parkinson's disease.
==See also== Etilevodopa Foslevodopa XP-21279