MYH1

Also known as HEL71, MYHSA1, MYHa, MyHC-2X/D, MyHC-2x, myosin, heavy chain 1, skeletal muscle, adult, myosin heavy chain 1

Myosin-1, also known as 'striated muscle myosin heavy chain 1', is a protein that in humans is encoded by the MYH1 gene. This gene is most highly expressed in fast type IIX/D muscle fibres of vertebrates and encodes a protein found uniquely in striated muscle; it is a class II myosin with a long coiled coil tail that dimerizes and should not be confused with 'Myosin 1' encoded by the MYO1 family of genes (MYO1A-MYO1H). Class I MYO1 genes function in many cell types throughout biology and are single-headed membrane-binding myosins that lack a long coiled coil tail.

In the Vinony graph

Vinony's link graph records 271 inbound references to MYH1, and connects out to hair keratin, PubMed and human chromosome 17.

It is catalogued under the topic Genes on human chromosome 17.

Vinony links it to 7 Wikipedia language editions.

Gene data

MYH1

Name: myosin heavy chain 1
Type: protein-coding
Position: 10,491,027–10,518,719 (−)
Aliases: HEL71, MYHSA1, MYHa, MyHC-2X/D, MyHC-2x
Ensembl: ENSG00000109061
RefSeq RNA: NM_005963.4, XM_017024675.2, XM_054316233.1
RefSeq protein: NP_005954.3, XP_016880164.1, XP_054172208.1

Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008].