MYO15A
Sign in to saveAlso known as DFNB3, MYO15, myosin XVA
Unconventional myosin-XV is a protein that in humans is encoded by the MYO15A gene.
In the Vinony graph
Vinony's link graph records 273 inbound references to MYO15A, and connects out to hair keratin, PubMed and human chromosome 17.
It is catalogued under the topic Genes on human chromosome 17.
Vinony links it to 6 Wikipedia language editions.
Gene data
MYO15A- Name
- myosin XVA
- Type
- protein-coding
- Position
- 18,108,756–18,179,802 (+)
- Aliases
- DFNB3, MYO15
- Ensembl
- ENSG00000091536
- RefSeq RNA
- NM_016239.4, XM_011523918.3, XM_017024714.3, XM_017024715.3, XM_024450780.2
- RefSeq protein
- NP_057323.3, XP_011522220.1, XP_016880203.1, XP_016880204.1, XP_024306548.1
This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
myosin XVA
- Symbol
- MYO15A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:18,108,756-18,179,802
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 56504
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/51168
- genomic end
- 18179802
- genomic start
- 18108756
- chromosome
- human chromosome 17
- cytogenetic location
- 17p11.2
- genetic association
- nonsyndromic deafness
- expressed in
- sural nerve
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Gene
- Function
- Clinical significance
- References
- Further reading
Unconventional myosin-XV is a protein that in humans is encoded by the MYO15A gene.
== Gene ==
Excerpted from Wikipedia’s “MYO15A” article, available under the CC BY-SA 4.0 licence.