Structure via PubChem · Public domain (PubChem)
oxaprozin
Sign in to saveAlso known as Daypro®, WY-21743, Deflam, Walix, Danoprox, Oxaprozinum, Oxaprozina
Oxaprozin, also known as oxaprozinum, is a nonsteroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. Chemically, it is a propionic acid derivative. Safety and efficacy has been established in children over 6 years with juvenile rheumatoid arthritis only, and there is an increased risk of adverse reactions in the elderly population.
In the Vinony graph
Within Vinony's link graph, oxaprozin is referenced by 490 other articles, and connects out to salicylic acid, metamizole sodium and clonixin.
It sits within the topics Drugboxes which contain changes to verified fields, Drugs with non-standard legal status and ECHA InfoCard ID from Wikidata.
Its subject is documented across 18 Wikipedia language editions.
Chemical data
- Formula
- C18H15NO3
- Molecular weight
- 293.3 g/mol
- IUPAC name
- 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
- SMILES
- C1=CC=C(C=C1)C2=C(OC(=N2)CCC(=O)O)C3=CC=CC=C3
- InChIKey
- OFPXSFXSNFPTHF-UHFFFAOYSA-N
- XLogP
- 4.2
- Polar surface area
- 63.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1992
- Admin. routes
- oral
- Indications
- rheumatic disease, rheumatoid arthritis, juvenile idiopathic arthritis, osteoarthritis
via ChEMBL · EBI
Research
195 papers- Oxaprozin.2012
- Oxaprozin.2006
- Oxaprozin: a new NSAID.Orthopaedic review · 1992
- Clinical pharmacokinetics of oxaprozin.Clinical pharmacokinetics · 1998
- Oxaprozin. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.Drugs · 1986
via PubMed
Wikidata facts
- Subclass of
- non-steroidal anti-inflammatory drug
- Mass
- 293.105
- Has use
- medication
Show 9 more facts
- chemical formula
- C₁₈H₁₅NO₃
- medical condition treated
- rheumatoid arthritis
- canonical SMILES
- C1=CC=C(C=C1)C2=C(OC(=N2)CCC(=O)O)C3=CC=CC=C3
- World Health Organisation international non-proprietary name
- oxaprozin
- defined daily dose
- 0.9
- subject has role
- non-steroidal anti-inflammatory drug
- physically interacts with
- Prostaglandin-endoperoxide synthase 1
- Commons category
- Oxaprozin
- legal status (medicine)
- boxed warning
Sources (6)
via Wikidata · CC0
~4 min read
Encyclopedic overview
7 sectionsContents
- Medical uses
- Adverse effects
- History
- Society and culture
- FDA approval
- Recalls
- References
Oxaprozin, also known as oxaprozinum, is a nonsteroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. Chemically, it is a propionic acid derivative. Safety and efficacy has been established in children over 6 years with juvenile rheumatoid arthritis only, and there is an increased risk of adverse reactions in the elderly population.
It was patented in 1967 and approved for medical use in 1983.
Excerpted from Wikipedia’s “oxaprozin” article, available under the CC BY-SA 4.0 licence.