Petidina

Also known as meperidine

narcótico analgésico

OverviewAI-generated

Pethidine is a chemical compound with the IUPAC name ethyl 1-methyl-4-phenylpiperidine-4-carboxylate. Its chemical formula is C₁₅H₂₁NO₂, and it has a molecular weight of 247.33. The substance possesses a charge of 0, an xlogp value of 2.5, and a topological polar surface area of 29.5. It contains three hydrogen bond acceptors and no hydrogen bond donors.

The compound is identified by the MCN code 2933.33.81. In scientific literature, pethidine is the subject of 8,226 PubMed entries. It is also referenced by 2,255 other encyclopedia articles.

Synthesized by Vinony from 18 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Chemical data

Formula: C15H21NO2
Molecular weight: 247.33 g/mol
IUPAC name: ethyl 1-methyl-4-phenylpiperidine-4-carboxylate
SMILES: CCOC(=O)C1(CCN(CC1)C)C2=CC=CC=C2
InChIKey: XADCESSVHJOZHK-UHFFFAOYSA-N
XLogP: 2.5
Polar surface area: 29.5 Å²
H-bond donors: 0
H-bond acceptors: 3
Formal charge: 0

via PubChem

Research

8,226 papers

Epidural pethidine: pharmacology and clinical experience.Anaesthesia and intensive care · 1998
Pethidine.British medical journal · 1947
Is Pethidine Safe during Labor? Systematic Review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2017
Clinical pharmacokinetics of pethidine.Clinical pharmacokinetics · 1978
Intrathecal pethidine: pharmacology and clinical applications.Anaesthesia and intensive care · 1998

via PubMed

Wikidata facts

Has part: hydrogen
Mass: 247.157229
Manufacturer: Pfizer
Has use: medication

Show 6 more facts

MCN code: 2933.33.81
chemical formula: C₁₅H₂₁NO₂
significant drug interaction: clozapine
Commons category: Pethidine
canonical SMILES: CCOC(=O)C1(CCN(CC1)C)C2=CC=CC=C2
medical condition treated: pain

Sources (5)

via Wikidata · CC0

Article · Español

La petidina (DCI), generalmente conocida como meperidina, es un narcótico analgésico que actúa como depresor del sistema nervioso central y se utiliza para aliviar el dolor de intensidad media o alta. La petidina pertenece al grupo de los opioides síntéticos, más concretamente a la familia de las fenilpiperidinas (familia con estructura y propiedades farmacológicas diferentes a los fármacos de la familia de las fenilpropilaminas como por ejemplo la metadona). Al igual que otros opioides, causa dependencia y síndrome de abstinencia si se deja de tomar de forma repentina tras varios días de administración, por lo que la dosis debe retirarse de forma gradual. Tiene la propiedad única entre los opioides de producir bloqueo de los canales iónicos, de esta forma también provee analgesia mediante un mecanismo anestésico local.

Abstract from DBpedia / Wikipedia · CC BY-SA