PICALM

Also known as CALM, CLTH, LAP, phosphatidylinositol binding clathrin assembly protein

Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the PICALM gene.

In the Vinony graph

Within Vinony's link graph, PICALM is referenced by 7 other articles, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 11.

Its subject is documented across 6 Wikipedia language editions.

Gene data

PICALM

Name: phosphatidylinositol binding clathrin assembly protein
Type: protein-coding
Position: 85,957,157–86,069,882 (−)
Aliases: CALM, CLTH, LAP
Ensembl: ENSG00000073921
RefSeq RNA: NM_001008660.3, NM_001206946.2, NM_001206947.2, NM_001411034.1, NM_007166.4
RefSeq protein: NP_001008660.1, NP_001193875.1, NP_001193876.1, NP_001397963.1, NP_009097.2

This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].