Structure via PubChem · Public domain (PubChem)
picotamide
Sign in to savePicotamide is a platelet aggregation inhibitor. It works as a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses to activation of the thromboxane receptor. Picotamide is licensed in Italy for the treatment of clinical arterial thrombosis and peripheral artery disease.
Chemical data
- Formula
- C21H20N4O3
- Molecular weight
- 376.4 g/mol
- IUPAC name
- 4-methoxy-1-N,3-N-bis(pyridin-3-ylmethyl)benzene-1,3-dicarboxamide
- SMILES
- COC1=C(C=C(C=C1)C(=O)NCC2=CN=CC=C2)C(=O)NCC3=CN=CC=C3
- InChIKey
- KYWCWBXGRWWINE-UHFFFAOYSA-N
- XLogP
- 1.3
- Polar surface area
- 93.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- Recurrent thrombophlebitis
via ChEMBL · EBI
Research
117 papers- Picotamide inhibits a wide spectrum of agonist-induced smooth muscle contractions in porcine renal interlobar and coronary arteries.Pharmacology research & perspectives · 2021
- A review of picotamide in the reduction of cardiovascular events in diabetic patients.Vascular health and risk management · 2007
- Picotamide, a combined inhibitor of thromboxane A2 synthase and receptor, reduces 2-year mortality in diabetics with peripheral arterial disease: the DAVID study.European heart journal · 2004
- Mechanism of the persisting TxA2 receptor antagonism by picotamide.Thrombosis research · 1997
- Picotamide in migraine aura prevention: a pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2004
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 376.154
Show 4 more facts
- chemical formula
- C₂₁H₂₀N₄O₃
- canonical SMILES
- COC1=C(C=C(C=C1)C(=O)NCC2=CN=CC=C2)C(=O)NCC3=CN=CC=C3
- subject has role
- platelet aggregation inhibitors
- physically interacts with
- Thromboxane A synthase 1
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Picotamide is a platelet aggregation inhibitor. It works as a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses to activation of the thromboxane receptor. Picotamide is licensed in Italy for the treatment of clinical arterial thrombosis and peripheral artery disease.
== References ==
Excerpted from Wikipedia’s “picotamide” article, available under the CC BY-SA 4.0 licence.
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via Wikidata sitelinks · CC0