Structure via PubChem · Public domain (PubChem)
piperazine
Sign in to saveAlso known as Piperazidine, Diethylenediamine, Vermizine (tn), Piperazin, Hexahydropyrazine, 1,4-Diazinane
Piperazine () is an organic compound with the formula . In terms of its structure, it can be described as cyclohexane with the 1- and 4-CH2 groups replaced by NH. Piperazine exists as a deliquescent solid with a saline taste. Piperazine is freely soluble in water and ethylene glycol, but poorly soluble in diethyl ether. Piperazine is commonly available industrially as the hexahydrate, , which melts at 44 °C and boils at 125–130 °C.
Chemical data
- Formula
- C4H10N2
- Molecular weight
- 86.14 g/mol
- IUPAC name
- piperazine
- SMILES
- C1CNCCN1
- InChIKey
- GLUUGHFHXGJENI-UHFFFAOYSA-N
- XLogP
- -1.5
- Polar surface area
- 24.1 Ų
- H-bond donors
- 2
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
98,399 papers- Morpholine, Piperazine, and Piperidine Derivatives as Antidiabetic Agents.Molecules (Basel, Switzerland) · 2024
- Piperazine-based P2X4 receptor antagonists.Archiv der Pharmazie · 2025
- Synthetic Protocols, Structural Activity Relationship, and Biological Activity of Piperazine and its Derivatives.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2024
- Novel Piperazine Derivatives of Vindoline as Anticancer Agents.International journal of molecular sciences · 2024
- Recent advances in the synthesis of piperazine based ligands and metal complexes and their applications.Dalton transactions (Cambridge, England : 2003) · 2021
via PubMed
Wikidata facts
- Mass
- 86.084
Show 5 more facts
- canonical SMILES
- C1CNCCN1
- chemical formula
- C₄H₁₀N₂
- Commons category
- Piperazine
- defined daily dose
- 3.5
- melting point
- 110
Sources (3)
via Wikidata · CC0
~5 min read
Article
11 sectionsContents
- Origin and naming
- Synthesis and structure
- Reactions
- Uses
- As an anthelmintic
- Piperazine derivatives as drugs
- Other uses
- Safety
- See also
- References
- External links
Piperazine () is an organic compound with the formula . In terms of its structure, it can be described as cyclohexane with the 1- and 4-CH2 groups replaced by NH. Piperazine exists as a deliquescent solid with a saline taste. Piperazine is freely soluble in water and ethylene glycol, but poorly soluble in diethyl ether. Piperazine is commonly available industrially as the hexahydrate, , which melts at 44 °C and boils at 125–130 °C.
Substituted derivatives of piperazine are a broad class of chemical compounds. Many piperazines have useful pharmacological properties, with prominent examples including sildenafil, ciprofloxacin, and ziprasidone.