Structure via PubChem · Public domain (PubChem)
pyrantel
Sign in to saveAlso known as pirantel
Pyrantel is a medication used to treat a number of parasitic worm infections. This includes ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis. It is taken by mouth.
Key facts
- Drug.IUPAC_name
- 1-Methyl-2-[(E)-2-(2-thienyl)vinyl]-5,6-dihydro-4H-pyrimidine
- Drug.image
- Pyrantel skeletal formula.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Pyrantel ball-and-stick model from PubChem 708857 optimized.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Pin-X, Combantrin, others
- Drug.pregnancy_US
- C
- Drug.routes_of_administration
- by mouth
- Drug.legal_US
- OTC
- Drug.bioavailability
- poorly absorbed
- Drug.CAS_number
- 15686-83-6
- Drug.ATC_prefix
- P02
- Drug.ATC_suffix
- CC01
- Drug.PubChem
- 708857
- Drug.DrugBank
- DB11156
- Drug.ChemSpiderID
- 618121
- Drug.UNII
- 4QIH0N49E7
- Drug.KEGG
- D08451
via Wikipedia infobox
Chemical data
- Formula
- C11H14N2S
- Molecular weight
- 206.31 g/mol
- IUPAC name
- 1-methyl-2-[(E)-2-thiophen-2-ylethenyl]-5,6-dihydro-4H-pyrimidine
- SMILES
- CN1CCCN=C1/C=C/C2=CC=CS2
- InChIKey
- YSAUAVHXTIETRK-AATRIKPKSA-N
- XLogP
- 1.6
- Polar surface area
- 43.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
1,117 papers- Pyrantel pamoate for pinworm infestation.American pharmacy · 1993
- Pyrantel resistance in canine hookworms in Queensland, Australia.Veterinary parasitology, regional studies and reports · 2024
- Pyrantel in small animal medicine: 30 years on.Veterinary journal (London, England : 1997) · 2008
- Antiminth (pyrantel pamoate).Clinical pediatrics · 1974
- Safety of Simparica Trio(®) (sarolaner, pyrantel, moxidectin) in heartworm-infected dogs.Parasites & vectors · 2023
via PubMed
~2 min read
Encyclopedic overview
5 sectionsContents
- Pregnancy and breastfeeding
- Mechanism of action
- Names
- References
- External links
Pyrantel is a medication used to treat a number of parasitic worm infections. This includes ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis. It is taken by mouth.
Side effects include nausea, headache, dizziness, trouble sleeping, and rash. A lower dose should be used in people with liver disease. While it does not appear to be harmful during pregnancy, it has not been studied for this use. It is unclear if it is safe for use during breastfeeding. It is in the antihelmintic family of medications. It works by paralyzing worms.
Excerpted from Wikipedia’s “pyrantel” article, available under the CC BY-SA 4.0 licence.