PPARG

Also known as CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator activated receptor gamma, PPARG5

protein-coding gene in the species Homo sapiens

Gene data

PPARG

Name: peroxisome proliferator activated receptor gamma
Type: protein-coding
Position: 12,287,368–12,434,574 (+)
Aliases: CIMT1, FPLD3, GLM1, NR1C3, PPARG1, PPARG2, PPARG5, PPARgamma
Ensembl: ENSG00000132170
RefSeq RNA: NM_001330615.4, NM_001354666.3, NM_001354667.3, NM_001354668.2, NM_001354669.2
RefSeq protein: NP_001317544.2, NP_001341595.2, NP_001341596.2, NP_001341597.1, NP_001341598.1

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008].