RAC2

Also known as EN-7, Gx, HSPC022, p21-Rac2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2), Rac family small GTPase 2, IMD73B, IMD73C

Rac2 (Ras-related C3 botulinum toxin substrate 2) is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RAC2.

Gene data

RAC2

Name: Rac family small GTPase 2
Type: protein-coding
Position: 37,225,270–37,259,594 (−)
Aliases: EN-7, Gx, HSPC022, IMD73A, IMD73B, IMD73C, p21-Rac2
Ensembl: ENSG00000128340
RefSeq RNA: NM_002872.5, XM_006724286.4, XM_054325803.1
RefSeq protein: NP_002863.1, XP_006724349.1, XP_054181778.1

This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013].

Gene Ontology

Biological process

chemotaxis

Article

5 sections

Contents

Interactions
See also
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Further reading
External links

Members of Rho family of GTPases appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.