Structure via PubChem · Public domain (PubChem)
raltitrexed
Sign in to saveAlso known as ICI-D-1694, Tomudex®, ZD1694, Tomudex
Raltitrexed (Thaltitrexed, Tomudex, TDX, ZD 1694) is an antimetabolite drug used in cancer chemotherapy. It is an inhibitor of thymidylate synthase, and is manufactured by AstraZeneca.
In the Vinony graph
Vinony's link graph records 277 inbound references to raltitrexed, and connects out to folic acid antagonists, tiazofurin and digital object identifier.
Vinony files it under Antifolates, Drugs developed by AstraZeneca and Drugs with non-standard legal status.
Vinony links it to 6 Wikipedia language editions.
Chemical data
- Formula
- C21H22N4O6S
- Molecular weight
- 458.5 g/mol
- IUPAC name
- (2S)-2-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic acid
- SMILES
- CC1=NC(=O)C2=C(N1)C=CC(=C2)CN(C)C3=CC=C(S3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
- InChIKey
- IVTVGDXNLFLDRM-HNNXBMFYSA-N
- XLogP
- 1.4
- Polar surface area
- 177 Ų
- H-bond donors
- 4
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Admin. routes
- parenteral
- Indications
- neoplasm, mesothelioma, squamous cell carcinoma, rectum cancer
via ChEMBL · EBI
Research
831 papers- Raltitrexed in mesothelioma.Expert review of anticancer therapy · 2011
- Raltitrexed-based chemotherapy for advanced colorectal cancer.Clinics and research in hepatology and gastroenterology · 2014
- Raltitrexed: optimism and reality.Expert opinion on drug metabolism & toxicology · 2009
- Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.Science (New York, N.Y.) · 2013
- Raltitrexed: current clinical status and future directions.Annals of oncology : official journal of the European Society for Medical Oncology · 2002
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 458.126
- Has use
- medication
Show 6 more facts
- chemical formula
- C₂₁H₂₂N₄O₆S
- canonical SMILES
- CC1=NC(=O)C2=C(N1)C=CC(=C2)CN(C)C3=CC=C(S3)C(=O)NC(CCC(=O)O)C(=O)O
- isomeric SMILES
- CC1=NC(=O)C2=C(N1)C=CC(=C2)CN(C)C3=CC=C(S3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
- subject has role
- folic acid antagonists
- physically interacts with
- Thymidylate synthetase
- Commons category
- Raltitrexed
via Wikidata · CC0
~3 min read
Encyclopedic overview
3 sectionsContents
- Uses
- Mechanism of action
- References
{{Drugbox | verifiedrevid = 464379925 | IUPAC_name = N-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]amino}-2-thienyl)carbonyl]-L-glutamic acid | image = Raltitrexed.svg | image_class = skin-invert-image | image2 = Raltitrexed ball-and-stick.png | image_class2 = bg-transparent
| tradename = | Drugs.com = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_UK = POM | legal_US = Not available | legal_status = | routes_of_administration = Intravenous
Excerpted from Wikipedia’s “raltitrexed” article, available under the CC BY-SA 4.0 licence.