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GeneQ18037684· pop 6· linked from 5 articles

RASGRP3

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Also known as GRP3, RAS guanyl releasing protein 3

Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene.

Gene data

RASGRP3

Name: RAS guanyl releasing protein 3
Type: protein-coding
Position: 33,436,272–33,586,669 (+)
Aliases: GRP3
Ensembl: ENSG00000152689
RefSeq RNA: NM_001139488.2, NM_001349975.2, NM_001349976.2, NM_001349977.2, NM_001349978.2
RefSeq protein: NP_001132960.1, NP_001336904.1, NP_001336905.1, NP_001336906.1, NP_001336907.1

The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017].

Gene Ontology

Biological process

MAPK cascade small GTPase-mediated signal transduction small GTPase-mediated signal transduction Ras protein signal transduction Ras protein signal transduction

Molecular function

guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity GTPase activator activity calcium ion binding calcium ion binding protein binding kinase binding

Cellular component

cytoplasm plasma membrane plasma membrane plasma membrane guanyl-nucleotide exchange factor complex perinuclear region of cytoplasm

Pathways

MAPK signaling pathway - Homo sapiens (human)Ras signaling pathway - Homo sapiens (human)Rap1 signaling pathway - Homo sapiens (human)B cell receptor signaling pathway - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Downstream signaling events of B Cell Receptor (BCR)Downstream signaling events of B Cell Receptor (BCR)Activation of RAS in B cells Activation of RAS in B cells Adaptive Immune System

via MyGene.info

Gene · Ensembl

RAS guanyl releasing protein 3

Symbol: RASGRP3
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:33,436,267-33,586,669
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 15019
exact match: identifiers.org/ncbigene/25780
genomic end: 33789817
genomic start: 33661391
cytogenetic location: 2p22.3

Sources (5)

via Wikidata · CC0

~1 min read

Article

4 sections

Contents

Function
Interactions
References
Further reading

Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene.

== Function ==

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Categories

EF-hand-containing proteins Genes on human chromosome 2