RASGRP4
Sign in to saveAlso known as RAS guanyl releasing protein 4
RAS guanyl releasing protein 4 is a protein in humans that is encoded by the RASGRP4 gene in chromosome 19.
In the Vinony graph
Within Vinony's link graph, RASGRP4 is referenced by 4 other articles, and connects out to human chromosome 19, protein and gene.
It is catalogued under the topic Genes on human chromosome 19.
Its subject is documented across 5 Wikipedia language editions.
Gene data
RASGRP4- Name
- RAS guanyl releasing protein 4
- Type
- protein-coding
- Position
- 38,409,051–38,426,305 (−)
- Ensembl
- ENSG00000171777
- RefSeq RNA
- NM_001146202.2, NM_001146203.2, NM_001146204.2, NM_001146205.2, NM_001146206.2
- RefSeq protein
- NP_001139674.1, NP_001139675.1, NP_001139676.1, NP_001139677.1, NP_001139678.1
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
RAS guanyl releasing protein 4
- Symbol
- RASGRP4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:38,409,051-38,426,305
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 15635
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/115727
- chromosome
- human chromosome 19
- genomic start
- 38899695
- genomic end
- 38916945
- cytogenetic location
- 19q13.2
- expressed in
- right coronary artery
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
RAS guanyl releasing protein 4 is a protein in humans that is encoded by the RASGRP4 gene in chromosome 19.
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009].
Excerpted from Wikipedia’s “RASGRP4” article, available under the CC BY-SA 4.0 licence.