RASGRP1
Sign in to saveAlso known as CALDAG-GEFI, CALDAG-GEFII, RASGRP, hRasGRP1, RAS guanyl releasing protein 1, IMD64
RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene.
In the Vinony graph
Within Vinony's link graph, RASGRP1 is referenced by 8 other articles, and connects out to PubMed, human chromosome 15 and Ensembl genome database project.
It is catalogued under topics including EF-hand-containing proteins and Genes on human chromosome 15.
Its subject is documented across 6 Wikipedia language editions.
Gene data
RASGRP1- Name
- RAS guanyl releasing protein 1
- Type
- protein-coding
- Position
- 38,488,103–38,565,575 (−)
- Aliases
- CALDAG-GEFI, CALDAG-GEFII, IMD64, RASGRP
- Ensembl
- ENSG00000172575
- RefSeq RNA
- NM_001128602.2, NM_001306086.2, NM_005739.4, XM_047432073.1, XM_047432074.1
- RefSeq protein
- NP_001122074.1, NP_001293015.1, NP_005730.2, XP_047288029.1, XP_047288030.1
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
RAS guanyl releasing protein 1
- Symbol
- RASGRP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:38,488,103-38,565,575
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 4195
- genetic association
- type-1 diabetes
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10125
- genomic end
- 38857776
- genomic start
- 38780304
- chromosome
- human chromosome 15
- cytogenetic location
- 15q14
- expressed in
- middle temporal gyrus
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Function
- Gene
- Clinical significance
- References
- Further reading
- External links
RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene.
== Function ==
Excerpted from Wikipedia’s “RASGRP1” article, available under the CC BY-SA 4.0 licence.