Also known as CALDAG-GEFI, CALDAG-GEFII, RASGRP, hRasGRP1, RAS guanyl releasing protein 1, IMD64
RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene.
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008].
Biological process
RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene.
== Function ==
via MyGene.info
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).