SHOC2

Also known as SIAA0862, SOC2, SUR8, SHOC2 leucine-rich repeat scaffold protein, SHOC2, leucine rich repeat scaffold protein, SHOC2 leucine rich repeat scaffold protein, NSLH1

Gene data

SHOC2

Name: SHOC2 leucine rich repeat scaffold protein
Type: protein-coding
Aliases: NSLH1, SIAA0862, SOC2, SUR8

This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010].

via MyGene.info

Article

4 sections

Contents

Interactions
SHOC2 Dependent Dynamic Regulation of MAPK signaling
References
Further reading

thumb|Biological assembly of SHOC2 protein as shown by crystal structure to a resolution of 2.4 Angstrom. Sulfate molecules are labeled purple. Structure from 10.2210/pdb7TVG/pdb.thumb|SHOC2 protein leucine rich domain. Leucine amino acids shown as bright orange sticks.Leucine-rich repeat (LRR) protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene. The best-studied role of SHOC2 is in modulating signals of the extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathway by forming a holophosphatase complex that activates RAF proteins. This protein was initially identified in Caenorhabditis elegans as SUR-8/SOC2 and was found to be a critical positive regulator of the ERK1/2 signaling pathway that integrates the Ras and RAF components of the ERK1/2 pathway into a multiprotein complex. Specifically, SHOC2 tethers RAS and PP1C proteins and in close proximity to RAF to dephosphorylate “S259” to enable MAPK signaling. It has been shown that activity that results in lipidation (specifically Myristoylation) of SHOC2 can cause Noonan syndrome.

== Interactions ==