SIN3A
Sign in to saveAlso known as Paired amphipathic helix protein Sin3a, SIN3 transcription regulator family member A, WITKOS
Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.
Gene data
SIN3A- Name
- SIN3 transcription regulator family member A
- Type
- protein-coding
- Position
- 75,369,379–75,455,842 (−)
- Aliases
- CHR15DELq24, DEL15Q24, WITKOS
- Ensembl
- ENSG00000169375
- RefSeq RNA
- NM_001145357.2, NM_001145358.2, NM_001437462.1, NM_001437463.1, NM_015477.3
- RefSeq protein
- NP_001138829.1, NP_001138830.1, NP_001424391.1, NP_001424392.1, NP_056292.1
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
negative regulation of transcription by RNA polymerase IInegative regulation of transcription by RNA polymerase IInegative regulation of transcription by RNA polymerase IInegative regulation of transcription by RNA polymerase IIactivation of innate immune responsepositive regulation of defense response to virus by hostregulation of DNA-templated transcriptionregulation of hormone levels
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SIN3 transcription regulator family member A
- Symbol
- SIN3A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:75,369,379-75,455,842
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Research
635 papers- Regulation of the Methylation and Expression Levels of the BMPR2 Gene by SIN3a as a Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension.Circulation · 2021
- Sin3a drives mesenchymal-to-epithelial transition through cooperating with Tet1 in somatic cell reprogramming.Stem cell research & therapy · 2022
- SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability.Cell reports · 2024
- Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis.American journal of respiratory and critical care medicine · 2021
- Suppression of SIN3A by miR-183 Promotes Breast Cancer Metastasis.Molecular cancer research : MCR · 2022
via PubMed
Wikidata facts
- Image
- Protein SIN3A PDB 1g1e.png
Show 5 more facts
- HomoloGene ID
- 32124
- exact match
- identifiers.org/ncbigene/25942
- genomic end
- 75748183
- genomic start
- 75661720
- cytogenetic location
- 15q24.2
via Wikidata · CC0
~1 min read
Article
6 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
- External links
Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.
== Function ==
Connections
Q180686
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Ensembl genome database project
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protein
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Q229883
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