TLE3
Sign in to saveAlso known as ESG, ESG3, GRG3, HsT18976, transducin like enhancer of split 3, TLE family member 3, transcriptional corepressor
Transducin-like enhancer protein 3 is a protein that in humans is encoded by the TLE3 gene.
Gene data
TLE3- Name
- TLE family member 3, transcriptional corepressor
- Type
- protein-coding
- Aliases
- ESG, ESG3, GRG3, HsT18976
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013].
via MyGene.info
Gene · Ensembl
TLE family member 3, transcriptional corepressor
- Symbol
- TLE3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:70,047,774-70,098,176
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein TLE3 PDB 1gxr.png
Show 5 more facts
- HomoloGene ID
- 21059
- exact match
- identifiers.org/ncbigene/7090
- genomic end
- 70390515
- genomic start
- 70340129
- cytogenetic location
- 15q23
Sources (4)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Transducin-like enhancer protein 3 is a protein that in humans is encoded by the TLE3 gene.
TLE3 expression has been linked to higher survival rates for lung cancer patients.