TLE1
Sign in to saveAlso known as ESG, ESG1, GRG1, transducin like enhancer of split 1, TLE family member 1, transcriptional corepressor, TLE-1
Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.
In the Vinony graph
Within Vinony's link graph, TLE1 is referenced by 11 other articles, and connects out to PubMed, Ensembl genome database project and protein.
It is catalogued under the topic Genes on human chromosome 9.
Its subject is documented across 5 Wikipedia language editions.
Gene data
TLE1- Name
- TLE family member 1, transcriptional corepressor
- Type
- protein-coding
- Position
- 81,582,313–81,689,681 (−)
- Aliases
- ESG, ESG1, GRG1, TLE-1
- Ensembl
- ENSG00000196781
- RefSeq RNA
- NM_001303103.2, NM_001303104.2, NM_005077.5, XM_005252151.2, XM_005252152.2
- RefSeq protein
- NP_001290032.1, NP_001290033.1, NP_005068.2, XP_005252208.1, XP_005252209.1
Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
TLE family member 1, transcriptional corepressor
- Symbol
- TLE1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:81,582,313-81,689,681
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TLE1 PDB 1gxr.png
Show 8 more facts
- HomoloGene ID
- 21058
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7088
- genomic start
- 84198598
- chromosome
- human chromosome 9
- genomic end
- 81689547
- cytogenetic location
- 9q21.32
- expressed in
- middle temporal gyrus
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.
== Interactions ==
Excerpted from Wikipedia’s “TLE1” article, available under the CC BY-SA 4.0 licence.