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GeneQ17856022· pop 5· linked from 822 articles

RUNX3

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Also known as AML2, CBFA3, PEBP2aC, runt related transcription factor 3, RUNX family transcription factor 3

Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.

In the Vinony graph

Vinony's link graph records 822 inbound references to RUNX3, and connects out to PubMed, homeobox and Ensembl genome database project.

It sits within the topics Genes on human chromosome 1 and Transcription factors.

Vinony links it to 5 Wikipedia language editions.

Gene data

RUNX3

Name: RUNX family transcription factor 3
Type: protein-coding
Position: 24,899,511–24,965,121 (−)
Aliases: AML2, CBFA3, PEBP2aC
Ensembl: ENSG00000020633
RefSeq RNA: NM_001031680.2, NM_001320672.1, NM_004350.3, XM_005246024.5, XM_011542351.2
RefSeq protein: NP_001026850.1, NP_001307601.1, NP_004341.1, XP_005246081.1, XP_011540653.1

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II ossification chondrocyte differentiation regulation of DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription corepressor binding

Cellular component

chromatin chromatin chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

Th1 and Th2 cell differentiation - Homo sapiens (human)Epstein-Barr virus infection - Homo sapiens (human)Developmental Biology Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex Generic Transcription Pathway Generic Transcription Pathway Binding of TCF/LEF:CTNNB1 to target gene promoters

via MyGene.info

Gene · Ensembl

RUNX family transcription factor 3

Symbol: RUNX3
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:24,899,511-24,965,121
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein RUNX3 PDB 1cmo.png

Show 8 more facts

HomoloGene ID: 37914
chromosome: human chromosome 1
genetic association: Crohn's disease
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/864
genomic end: 25291612
genomic start: 25226002
cytogenetic location: 1p36.11

Sources (5)

via Wikidata · CC0

~4 min read

Encyclopedic overview

8 sections

Contents

Function
Knockout mouse
The RUNX3 controversy and resolution
Interactions
See also
References
Further reading
External links

Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.

== Function ==

Excerpted from Wikipedia’s “RUNX3” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 1 Transcription factors