English

English Deutsch Español Français Italiano Nederlands Português Svenska العربية

GeneQ18031936· pop 5· linked from 817 articles

TEAD4

Sign in to save

Also known as EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B, TEA domain transcription factor 4

Transcriptional enhancer factor TEAD4 (previously known as TEF-3) is a protein that in humans is encoded by the TEAD4 gene.

In the Vinony graph

Vinony's link graph records 817 inbound references to TEAD4, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.

It sits within the topics Genes on human chromosome 12 and Transcription factors.

Vinony links it to 5 Wikipedia language editions.

Gene data

TEAD4

Name: TEA domain transcription factor 4
Type: protein-coding
Position: 2,959,031–3,040,676 (+)
Aliases: EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B
Ensembl: ENSG00000197905
RefSeq RNA: NM_003213.4, NM_201441.3, NM_201443.3
RefSeq protein: NP_003204.2, NP_958849.1, NP_958851.1

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

skeletal system development DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II muscle organ development hippo signaling hippo signaling

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex transcription regulator complex cytoplasm

Pathways

Hippo signaling pathway - Homo sapiens (human)Hippo signaling pathway - multiple species - Homo sapiens (human)Developmental Biology Adaptive Immune System Immune System YAP1- and WWTR1 (TAZ)-stimulated gene expression Generic Transcription Pathway Regulation of T cell activation by CD28 family Co-inhibition by PD-1 RNA Polymerase II Transcription

via MyGene.info

Gene · Ensembl

TEA domain transcription factor 4

Symbol: TEAD4
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:2,959,031-3,040,676
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein TEAD4 PDB 2hzd.png

Show 8 more facts

HomoloGene ID: 74463
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/7004
genomic end: 3040676
genomic start: 3068496
chromosome: human chromosome 12
cytogenetic location: 12p13.33
expressed in: biceps brachii

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
References
Further reading
External links

Transcriptional enhancer factor TEAD4 (previously known as TEF-3) is a protein that in humans is encoded by the TEAD4 gene.

== Function ==

Excerpted from Wikipedia’s “TEAD4” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 12 Transcription factors