treprostinil

Also known as LRX-15, ({(1R,2R,3aS,9aS)-2-Hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphtalen-5-yl}oxy)acetic acid, (1R,2R,3aS,9aS)-({2,3,3a,4,9,9a-hexahydro-2-hydroxy- 1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl}oxy)acetic acid

Treprostinil, sold under the brand names Remodulin for infusion, Orenitram for oral, and Tyvaso for inhalation among others, is a vasodilator that is used for the treatment of pulmonary arterial hypertension.

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 477864833
Drug.image: Treprostinil.svg
Drug.image_class: skin-invert-image
Drug.width: 250
Drug.image2: Treprostinil2.png
Drug.image_class2: bg-transparent
Drug.tradename: Remodulin, Orenitram, Tyvaso, others
Drug.MedlinePlus: a622038
Drug.DailyMedID: Treprostinil
Drug.pregnancy_AU: B3
Drug.routes_of_administration: Subcutaneous, intravenous, inhalation, by mouth
Drug.ATC_prefix: B01
Drug.ATC_suffix: AC21
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only
Drug.legal_status: Rx-only

via Wikipedia infobox

Research

987 papers

Inhaled Treprostinil in Pulmonary Hypertension Due to Interstitial Lung Disease.The New England journal of medicine · 2021
Treprostinil Use in the NICU.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2024
Inhaled treprostinil and forced vital capacity in patients with interstitial lung disease and associated pulmonary hypertension: a post-hoc analysis of the INCREASE study.The Lancet. Respiratory medicine · 2021
Long-term inhaled treprostinil for pulmonary hypertension due to interstitial lung disease: INCREASE open-label extension study.The European respiratory journal · 2023
Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial.Journal of the American College of Cardiology · 2010

via PubMed

Wikidata facts

Mass: 390.241

Show 5 more facts

chemical formula: C₂₃H₃₄O₅
isomeric SMILES: CCCCC[C@@H](CC[C@H]1[C@@H](C[C@H]2[C@@H]1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
canonical SMILES: CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
World Health Organisation international non-proprietary name: treprostinil
defined daily dose: 4.3

Sources (4)

via Wikidata · CC0

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