tribendimidine

Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.

In the Vinony graph

Within Vinony's link graph, tribendimidine is referenced by 365 other articles, and connects out to quinoline, anthelmintic and pyrantel.

It is catalogued under topics including Amidines, Anthelmintics and Chemical pages without DrugBank identifier.

Its subject is documented across 7 Wikipedia language editions.

Chemical data

Formula: C28H32N6
Molecular weight: 452.6 g/mol
IUPAC name: N'-[4-[[4-[[4-[1-(dimethylamino)ethylideneamino]phenyl]iminomethyl]phenyl]methylideneamino]phenyl]-N,N-dimethylethanimidamide
SMILES: CC(=NC1=CC=C(C=C1)N=CC2=CC=C(C=C2)C=NC3=CC=C(C=C3)N=C(C)N(C)C)N(C)C
InChIKey: XOIOGKHKNQYULW-UHFFFAOYSA-N
XLogP: 3.8
Polar surface area: 55.9 Å²
H-bond donors: 0
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Molecule type: Small molecule

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 452.26884502400014

Show 2 more facts

chemical formula: C₂₈H₃₂N₆
canonical SMILES: CC(=NC1=CC=C(C=C1)N=CC2=CC=C(C=C2)C=NC3=CC=C(C=C3)N=C(C)N(C)C)N(C)C

Sources (2)

via Wikidata · CC0

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Encyclopedic overview

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Contents

References

Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.

In clinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis. It is also effective against clonorchiasis. However, animal studies suggest it is ineffective in treating Schistosoma mansoni or Fasciola hepatica disease. The drug has also performed well in trials against opisthorchiasis, curing about 70% of cases.

Excerpted from Wikipedia’s “tribendimidine” article, available under the CC BY-SA 4.0 licence.