UBA3
Sign in to saveAlso known as NAE2, UBE1C, hUBA3, ubiquitin like modifier activating enzyme 3
NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.
In the Vinony graph
Within Vinony's link graph, UBA3 is referenced by 110 other articles, and connects out to PubMed, human chromosome 3 and Ensembl genome database project.
It sits within the topics Genes on human chromosome 3 and Protein domains.
Its subject is documented across 6 Wikipedia language editions.
Gene data
UBA3- Name
- ubiquitin like modifier activating enzyme 3
- Type
- protein-coding
- Position
- 69,053,972–69,080,408 (−)
- Aliases
- NAE2, UBE1C, hUBA3
- Ensembl
- ENSG00000144744
- RefSeq RNA
- NM_001363861.1, NM_003968.4, NM_198195.2, NM_198197.1, XM_011534210.2
- RefSeq protein
- NP_001350790.1, NP_003959.3, NP_937838.1, XP_011532512.1, XP_054204301.1
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ubiquitin like modifier activating enzyme 3
- Symbol
- UBA3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:69,053,972-69,080,408
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein UBE1C PDB 1r4m.png
Show 7 more facts
- HomoloGene ID
- 2951
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9039
- genomic end
- 69129559
- genomic start
- 69103881
- chromosome
- human chromosome 3
- cytogenetic location
- 3p14.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Excerpted from Wikipedia’s “UBA3” article, available under the CC BY-SA 4.0 licence.