UBA3
Sign in to saveAlso known as NAE2, UBE1C, hUBA3, ubiquitin like modifier activating enzyme 3
NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.
Gene data
UBA3- Name
- ubiquitin like modifier activating enzyme 3
- Type
- protein-coding
- Aliases
- NAE2, UBE1C, hUBA3
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
ubiquitin like modifier activating enzyme 3
- Symbol
- UBA3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:69,053,972-69,080,408
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein UBE1C PDB 1r4m.png
Show 5 more facts
- HomoloGene ID
- 2951
- exact match
- identifiers.org/ncbigene/9039
- genomic end
- 69129559
- genomic start
- 69103881
- cytogenetic location
- 3p14.1
Sources (4)
via Wikidata · CC0
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4 sectionsContents
- Interactions
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- External links
NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.