ATG4D

Also known as APG4-D, APG4D, AUTL4, autophagy related 4D cysteine peptidase, HsAPG4D

The human ATG4D gene encodes the protein Autophagy related 4D, cysteine peptidase.

In the Vinony graph

Within Vinony's link graph, ATG4D is referenced by 2 other articles, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.

Vinony files it under Genes on human chromosome 19 and Human proteins.

Its subject is documented across 5 Wikipedia language editions.

Gene data

ATG4D

Name: autophagy related 4D cysteine peptidase
Type: protein-coding
Position: 10,543,533–10,553,556 (+)
Aliases: APG4-D, APG4D, AUTL4, HsAPG4D, SPGF101
Ensembl: ENSG00000130734
RefSeq RNA: NM_001281504.2, NM_032885.6, NR_104024.2, NR_104025.2, XM_006722927.2
RefSeq protein: NP_001268433.1, NP_116274.3, XP_006722990.1, XP_054178417.1

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].