Structure via PubChem · Public domain (PubChem)
bopindolol
Sign in to saveAlso known as Sandonorm
Bopindolol (), sold under the brand name Sandonorm among others, is a beta blocker used to treat hypertension. It has been marketed in a number of countries throughout the world, for instance in Europe.
In the Vinony graph
Vinony's link graph records 571 inbound references to bopindolol, and connects out to propranolol, adrenergic receptor and beta blocker.
It sits within the topics Benzoate esters, Beta blockers and Drugboxes which contain changes to verified fields.
Vinony links it to 16 Wikipedia language editions.
Chemical data
- Formula
- C23H28N2O3
- Molecular weight
- 380.5 g/mol
- IUPAC name
- [1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl] benzoate
- SMILES
- CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)OC(=O)C3=CC=CC=C3
- InChIKey
- UUOJIACWOAYWEZ-UHFFFAOYSA-N
- XLogP
- 4.7
- Polar surface area
- 63.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
139 papers- Bopindolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy.Drugs · 1991
- Bopindolol: pharmacological basis and clinical implications.Cardiovascular drug reviews · 2001
- Bopindolol: Czechoslovak experience with a new beta blocker in the treatment of hypertension.The American journal of cardiology · 1991
- Hypotensive effect of bopindolol in pithed rats.General pharmacology · 1993
- Bopindolol in chronic stable angina pectoris: duration and extent of antianginal action.British journal of clinical pharmacology · 1991
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 380.209993
- Has use
- medication
Show 3 more facts
- chemical formula
- C₂₃H₂₈N₂O₃
- canonical SMILES
- CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)OC(=O)C3=CC=CC=C3
- subject has role
- beta blocker
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Pharmacology
- Chemistry
- Synthesis
- History
- References
Bopindolol (), sold under the brand name Sandonorm among others, is a beta blocker used to treat hypertension. It has been marketed in a number of countries throughout the world, for instance in Europe.
==Pharmacology== Bopindolol is an ester prodrug of mepindolol. It acts as a non-selective or dual β1- and β2-adrenergic receptor antagonist. Bopindolol has intrinsic sympathomimetic activity (ISA) and membrane-stabilizing activity (MSA). Besides the β1- and β2-adrenergic receptors, bopindolol shows very low affinity for the β3-adrenergic receptor and interacts with certain serotonin receptors such as the serotonin 5-HT1A receptor with strong affinity.
Excerpted from Wikipedia’s “bopindolol” article, available under the CC BY-SA 4.0 licence.