Structure via PubChem · Public domain (PubChem)
bornaprine
Sign in to saveBornaprine (brand name Sormodrem) is a synthetic anticholinergic medication that is primarily used to treat Parkinson's disease. Additionally, bornaprine has been used to treat other disorders, including hyperhidrosis.
Chemical data
- Formula
- C21H31NO2
- Molecular weight
- 329.5 g/mol
- IUPAC name
- 3-(diethylamino)propyl 2-phenylbicyclo[2.2.1]heptane-2-carboxylate
- SMILES
- CCN(CC)CCCOC(=O)C1(CC2CCC1C2)C3=CC=CC=C3
- InChIKey
- BDNMABJZSXTKAQ-UHFFFAOYSA-N
- XLogP
- 4.7
- Polar surface area
- 29.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
19 papers- Bornaprine vs placebo in Parkinson disease: double-blind controlled cross-over trial in 30 patients.Italian journal of neurological sciences · 1986
- Effectiveness of bornaprine on parkinsonian tremor.Italian journal of neurological sciences · 1984
- [The disposition of bornaprine hydrochloride in the rat. 1. Pharmacokinetics: synthesis, plasma level and elimination].Arzneimittel-Forschung · 1989
- [Bornaprine in the treatment of parkinsonian tremor].Rivista di neurologia · 1985
- Influence of biperiden and bornaprine on sleep in healthy subjects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1994
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 329.235479
Show 4 more facts
- Commons category
- Bornaprine
- chemical formula
- C₂₁H₃₁NO₂
- canonical SMILES
- CCN(CC)CCCOC(=O)C1(CC2CCC1C2)C3=CC=CC=C3
- subject has role
- muscarinic antagonist
via Wikidata · CC0
~5 min read
Encyclopedic overview
15 sectionsContents
- History
- Pharmacodynamics
- Pharmacokinetics
- Absorption
- Excretion
- Metabolites
- Availability
- Treatment
- Parkinson's disease
- Hyperhidrosis
- Sleep
- Side effects
- Toxicity
- Synthesis
- References
Bornaprine (brand name Sormodrem) is a synthetic anticholinergic medication that is primarily used to treat Parkinson's disease. Additionally, bornaprine has been used to treat other disorders, including hyperhidrosis.
==History== Bornaprine was first synthesized in 1960 by the German scientist H Haas, under the name Kr 399. Additional tests revealed that bornaprine was significantly more effective than nicotine at antagonizing choline. Because of its anticholinergic effects, it was intended to help with the symptoms of Parkinson's. Early clinical trials with Parkinsonian patients (completed in Germany), showed that bornaprine was successful at treating many of the key side-effects of Parkinson's including akinesia, language, tremors, and psychological symptoms.
Excerpted from Wikipedia’s “bornaprine” article, available under the CC BY-SA 4.0 licence.