BST1
Sign in to saveAlso known as CD157, bone marrow stromal cell antigen 1
Bst1 (Bone marrow stromal cell antigen 1, ADP-ribosyl cyclase 2, CD157) is an enzyme that in humans is encoded by the BST1 gene. CD157 is a paralog of CD38, both of which are located on chromosome 4 (4p15) in humans.
Gene data
BST1- Name
- bone marrow stromal cell antigen 1
- Type
- protein-coding
- Position
- 15,702,993–15,775,614 (+)
- Aliases
- CD157, cADPR2
- Ensembl
- ENSG00000109743
- RefSeq RNA
- NM_004334.3, XM_005248185.3, XM_005248186.3, XM_011513878.4, XM_011513879.3
- RefSeq protein
- NP_004325.2, XP_005248242.1, XP_005248243.1, XP_011512180.1, XP_011512181.1
Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
bone marrow stromal cell antigen 1
- Symbol
- BST1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:15,702,993-15,775,614
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein BST1 PDB 1isf.png
Show 9 more facts
- HomoloGene ID
- 3198
- genetic association
- Parkinson's disease
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/683
- genomic end
- 15739936
- genomic start
- 15703065
- chromosome
- human chromosome 4
- cytogenetic location
- 4p15.32
- expressed in
- trabecular bone
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- See also
- References
- External links
- Further reading
Bst1 (Bone marrow stromal cell antigen 1, ADP-ribosyl cyclase 2, CD157) is an enzyme that in humans is encoded by the BST1 gene. CD157 is a paralog of CD38, both of which are located on chromosome 4 (4p15) in humans.
Bst1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population.
Excerpted from Wikipedia’s “BST1” article, available under the CC BY-SA 4.0 licence.