Structure via PubChem · Public domain (PubChem)
carbachol
Sign in to saveAlso known as CAR405, 2-(carbamoyloxy)-N,N,N-trimethylethanaminium, (2-hydroxyethyl)trimethylammonium chloride carbamate, (2-hydroxyethyl)trimethyl ammonium chloride carbamate, 2-[(aminocarbonyl)oxy]-N,N,N-trimethylethanaminum chloride, carbamylcholine, choline chlorine carbamate, 2-[(aminocarbonyl)oxy]-N,N,N-trimethylethanaminium chloride
Carbachol, also known as carbamylcholine and sold under the brand name Miostat among others, is a cholinomimetic drug that binds and activates acetylcholine receptors. Thus it is classified as a cholinergic agonist. It is primarily used for various ophthalmic purposes, such as for treating glaucoma, or for use during ophthalmic surgery. It is generally administered as an ophthalmic solution (i.e., eye drops).
Chemical data
- Formula
- C6H15ClN2O2
- Molecular weight
- 182.65 g/mol
- IUPAC name
- 2-carbamoyloxyethyl(trimethyl)azanium chloride
- SMILES
- C[N+](C)(C)CCOC(=O)N.[Cl-]
- InChIKey
- AIXAANGOTKPUOY-UHFFFAOYSA-N
- Polar surface area
- 52.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
19,551 papers- Carbachol dose response.American journal of ophthalmology · 1989
- Local carbachol application induces oral microvascular recruitment and improves gastric tissue oxygenation during hemorrhagic shock in dogs.Frontiers in immunology · 2024
- CARBACHOL AND VITAMIN B12 ABSORPTION.British medical journal · 1965
- Carbachol-induced sustained tonic contraction of rat detrusor muscle.BJU international · 1999
- Carbachol in cataract surgery.Archives of ophthalmology (Chicago, Ill. : 1960) · 1968
via PubMed
Wikidata facts
- Mass
- 182.082
Show 5 more facts
- defined daily dose
- 0.4
- chemical formula
- C₆H₁₅ClN₂O₂
- Commons category
- Carbachol
- World Health Organisation international non-proprietary name
- carbachol
- canonical SMILES
- C[N+](C)(C)CCOC(=O)N.[Cl-]
via Wikidata · CC0
~4 min read
Article
7 sectionsContents
- Chemistry and pharmacology
- Synthesis
- Indications
- Contraindications
- Overdose
- References
- External links
Carbachol, also known as carbamylcholine and sold under the brand name Miostat among others, is a cholinomimetic drug that binds and activates acetylcholine receptors. Thus it is classified as a cholinergic agonist. It is primarily used for various ophthalmic purposes, such as for treating glaucoma, or for use during ophthalmic surgery. It is generally administered as an ophthalmic solution (i.e., eye drops).
Carbachol produces effects comparable to those of sarin if a massive overdose is administered (as may occur following industrial and shipping accidents) and therefore it is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities.