CD74 molecule
Sign in to saveAlso known as CD74, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), Ii, gamma chain of class II antigens, HLA-DR-gamma, HLA-DR antigens-associated invariant chain, CD74 molecule, major histocompatibility complex, class II invariant chain, p33
HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene. The invariant chain (Abbreviated Ii) is a polypeptide which plays a critical role in antigen presentation. It is involved in the formation and transport of MHC class II peptide complexes for the generation of CD4+ T cell responses. The cell surface form of the invariant chain is known as CD74. CD74 is a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF).
Protein · UniProt
HLA class II histocompatibility antigen gamma chain
- Gene
- CD74
- Organism
- Homo sapiens (Human)
- Length
- 296 aa
- Molecular mass
- 33,516 Da
- Evidence
- 1: Evidence at protein level
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF
Swiss-Prot (reviewed) · via UniProt
~4 min read
Article
12 sectionsContents
- Function
- Clinical significance
- Vaccine adjuvant
- Cancer
- Axial spondyloarthritis
- Interactions
- Recovery functions
- History
- See also
- References
- Further reading
- External links
HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene. The invariant chain (Abbreviated Ii) is a polypeptide which plays a critical role in antigen presentation. It is involved in the formation and transport of MHC class II peptide complexes for the generation of CD4+ T cell responses. The cell surface form of the invariant chain is known as CD74. CD74 is a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF).
== Function == The nascent MHC class II protein in the rough endoplasmic reticulum (RER) binds a segment of the invariant chain (Ii; a trimer) in order to shape the peptide-binding groove and prevent the formation of a closed conformation.