CHD3

Also known as Mi-2a, Mi2-ALPHA, ZFH, chromodomain helicase DNA binding protein 3, SNIBCPS

Chromodomain-helicase-DNA-binding protein 3 is an enzyme that in humans is encoded by the CHD3 gene.

In the Vinony graph

Within Vinony's link graph, CHD3 is referenced by 11 other articles, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.

It sits within the topics Genes on human chromosome 17 and Long stubs with short prose.

Its subject is documented across 5 Wikipedia language editions.

Gene data

CHD3

Name: chromodomain helicase DNA binding protein 3
Type: protein-coding
Position: 7,884,787–7,912,760 (+)
Aliases: Mi-2a, Mi2-ALPHA, SNIBCPS, ZFH
Ensembl: ENSG00000170004
RefSeq RNA: NM_001005271.3, NM_001005273.3, NM_001272.1, NM_001437504.1, NM_001437507.1
RefSeq protein: NP_001005271.2, NP_001005273.1, NP_001424433.1, NP_001424436.1, NP_001424437.1

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].