Structure via PubChem · Public domain (PubChem)
cx516
Sign in to saveAlso known as BDP-12, CX 516, CX-516
CX-516 is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator and had been undergoing development by a collaboration between Cortex, Shire, and Servier. It was studied as a potential treatment for Alzheimer's disease under the brand name Ampalex, and was also being examined as a treatment for ADHD.
In the Vinony graph
Vinony's link graph records 833 inbound references to cx516, and connects out to AMPA receptor, pentamidine and 1-aminocyclopropanecarboxylic acid.
It sits within the topics 1-Piperidinyl compounds, Abandoned drugs and Ampakines.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C14H15N3O
- Molecular weight
- 241.29 g/mol
- IUPAC name
- piperidin-1-yl(quinoxalin-6-yl)methanone
- SMILES
- C1CCN(CC1)C(=O)C2=CC3=NC=CN=C3C=C2
- InChIKey
- ANDGGVOPIJEHOF-UHFFFAOYSA-N
- XLogP
- 1.8
- Polar surface area
- 46.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Cognitive impairment, schizophrenia
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 241.122
Show 2 more facts
- chemical formula
- C₁₄H₁₅N₃O
- canonical SMILES
- C1CCN(CC1)C(=O)C2=CC3=NC=CN=C3C=C2
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
CX-516 is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator and had been undergoing development by a collaboration between Cortex, Shire, and Servier. It was studied as a potential treatment for Alzheimer's disease under the brand name Ampalex, and was also being examined as a treatment for ADHD.
CX-516 was the first ampakine compound developed by Cortex and while it showed good in vitro activity and positive results in animal tests, the human trials proved disappointing due mainly to low potency and short half-life. However, CX-516 is still widely used in animal research into the ampakine drugs and is the standard reference compound that newer, more potent drugs of this class such as farampator and CX-717 are compared to.
Excerpted from Wikipedia’s “cx516” article, available under the CC BY-SA 4.0 licence.