Structure via PubChem · Public domain (PubChem)
NBQX
Sign in to saveAlso known as 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline
NBQX (2,3-dioxo-6-nitro-7-sulfamoyl-benzo[f]quinoxaline) is an antagonist of the AMPA receptor.
In the Vinony graph
Within Vinony's link graph, NBQX is referenced by 419 other articles, and connects out to ginkgolide, picrotoxin and DL-glutamic acid.
It is catalogued under topics including AMPA receptor antagonists, Chembox image size set and ECHA InfoCard ID from Wikidata.
Its subject is documented across 10 Wikipedia language editions.
Chemical data
- Formula
- C12H8N4O6S
- Molecular weight
- 336.28 g/mol
- IUPAC name
- 6-nitro-2,3-dioxo-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
1,770 papers- NBQX attenuates relapse of nicotine seeking but not nicotine and methamphetamine self-administration in rats.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2021
- Structural and interaction analysis of human lipocalin-type prostaglandin D synthase with the poorly water-soluble drug NBQX.The FEBS journal · 2023
- NBQX attenuates excitotoxic injury in developing white matter.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000
- NBQX blocks acute and late epileptogenic effects of perinatal hypoxia.Epilepsia · 1995
- Both ketamine and NBQX attenuate alcohol drinking in male Wistar rats.Neuroscience letters · 2018
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 336.016455
Show 4 more facts
- chemical formula
- C₁₂H₈N₄O₆S
- canonical SMILES
- C1=CC2=C3C(=CC(=C2C(=C1)S(=O)(=O)N)[N+](=O)[O-])NC(=O)C(=O)N3
- subject has role
- anxiolytic
- Commons category
- NBQX
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
NBQX (2,3-dioxo-6-nitro-7-sulfamoyl-benzo[f]quinoxaline) is an antagonist of the AMPA receptor.
NBQX blocks AMPA receptors in micromolar concentrations (~10–20 μM) and also blocks kainate receptors. In experiments, it is used to counter glutamate excitotoxicity. NBQX was found to have anticonvulsant activity in rodent seizure models.
Excerpted from Wikipedia’s “NBQX” article, available under the CC BY-SA 4.0 licence.