Structure via PubChem · Public domain (PubChem)
EEDQ
Sign in to saveAlso known as 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
'''N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ''') is a dopamine-receptor antagonist.
In the Vinony graph
Vinony's link graph records 445 inbound references to EEDQ, and connects out to digital object identifier, chemical formula and melting point.
It sits within the topics Carbamates, ECHA InfoCard ID from Wikidata and Ethoxy compounds.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C14H17NO3
- Molecular weight
- 247.29 g/mol
- IUPAC name
- ethyl 2-ethoxy-2H-quinoline-1-carboxylate
- SMILES
- CCOC1C=CC2=CC=CC=C2N1C(=O)OCC
- InChIKey
- GKQLYSROISKDLL-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 38.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
411 papers- Irreversible antagonism of 5HT2c receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ).Proceedings of the National Academy of Sciences of the United States of America · 1997
- N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ): a new tool to probe CNS receptor function.Advances in experimental medicine and biology · 1988
- Effects of EEDQ on the synthesis and metabolism of dopamine in preweanling and adult rats.Neuropharmacology · 1994
- EEDQ, a tool for ex vivo measurement of occupancy of D-1 and D-2 dopamine receptors.European journal of pharmacology · 1988
- Ontogenetic effects of EEDQ on amphetamine-induced behaviors of rats: role of presynaptic processes.Psychopharmacology · 1994
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 247.121
Show 4 more facts
- subject has role
- serotonin antagonist
- melting point
- 65
- canonical SMILES
- CCOC1C=CC2=CC=CC=C2N1C(=O)OCC
- chemical formula
- C₁₄H₁₇NO₃
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
'''N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ') is a dopamine-receptor antagonist.
EEDQ is also a highly specific reagent for carboxyl groups. It enables the coupling of acylamino acids with amino acid esters in high yield and without racemization.
Excerpted from Wikipedia’s “EEDQ” article, available under the CC BY-SA 4.0 licence.