Structure via PubChem · Public domain (PubChem)
cyclopenthiazide
Sign in to saveAlso known as cyclomethiazide, SU-8341, NAX341
Cyclopenthiazide (trade name Navidrex) is a thiazide diuretic used in the treatment of heart failure and hypertension.
In the Vinony graph
Within Vinony's link graph, cyclopenthiazide is referenced by 76 other articles, and connects out to collecting duct system, Na-K-Cl cotransporter and medication.
Vinony files it under Benzothiadiazines, Chemical pages without DrugBank identifier and Chloroarenes.
Its subject is documented across 9 Wikipedia language editions.
Chemical data
- Formula
- C13H18ClN3O4S2
- Molecular weight
- 379.9 g/mol
- IUPAC name
- 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
- SMILES
- C1CCC(C1)CC2NC3=CC(=C(C=C3S(=O)(=O)N2)S(=O)(=O)N)Cl
- InChIKey
- BKYKPTRYDKTTJY-UHFFFAOYSA-N
- XLogP
- 1.3
- Polar surface area
- 135 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
175 papers- Drug-induced pancreatitis: an update.Journal of clinical gastroenterology · 2005
- [Cyclopenthiazide therapy].[Sogo rinsho] Clinic all-round · 1963
- [ON CYCLOPENTHIAZIDE (AWD-DRESDEN) THERAPY].Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete · 1964
- The case for low dose diuretics in hypertension: comparison of low and conventional doses of cyclopenthiazide.BMJ (Clinical research ed.) · 1988
- Xipamide and cyclopenthiazide in essential hypertension--comparative effects on blood pressure and plasma potassium.British journal of clinical pharmacology · 1982
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 379.042726
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₃H₁₈ClN₃O₄S₂
- canonical SMILES
- C1CCC(C1)CC2NC3=CC(=C(C=C3S(=O)(=O)N2)S(=O)(=O)N)Cl
- medical condition treated
- arterial hypertension
- World Health Organisation international non-proprietary name
- cyclopenthiazide
- defined daily dose
- 0.5
Sources (6)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Synthesis
- Contraindications
- See also
- References
Cyclopenthiazide (trade name Navidrex) is a thiazide diuretic used in the treatment of heart failure and hypertension.
==Synthesis== thumb|center|700px|Cyclopenthiazide synthesis:
Excerpted from Wikipedia’s “cyclopenthiazide” article, available under the CC BY-SA 4.0 licence.
Available in 9 languages
via Wikidata sitelinks · CC0