dextromoramide
Sign in to saveAlso known as (+)-1-(3-methyl-4-morpholino-2,2-diphenylbutyryl)pyrrolidine, (+)-4-(2-methyl-4-oxo-3,3-diphenyl-4-(1-pyrrolidinyl)butyl)morpholine, D-2,2-diphenyl-3-methyl-4-morpholinobutyrylpyrrolidine, R 875, SKF 5137, (+)-2,2-diphenyl-3-methyl-4-morpholinobutyrylpyrrolidine, (+)-3-methyl-4-morpholino-2,2-diphenyl-1-(pyrrolidin-1-yl)butanone, SKF-5137
Dextromoramide (Palfium, Palphium, Jetrium, Dimorlin) is a powerful opioid analgesic approximately three times more potent than morphine but shorter acting. It is subject to drug prohibition regimes, both internationally through UN treaties and by the criminal law of individual nations, and is usually prescribed only in the Netherlands.
Research
408 papers- Dextromoramide pharmacokinetics following sublingual administration.Palliative medicine · 1996
- Effect of methadone and dextromoramide on dopamine metabolism: comparison with haloperidol and amphetamine.Neuropharmacology · 1975
- Dependence on dextromoramide.British medical journal · 1967
- ADDICTION TO DEXTROMORAMIDE.British medical journal · 1964
- [Dextromoramide (R 875)].Revista medica de Chile · 1959
via PubMed
Wikidata facts
- Mass
- 392.246
Show 7 more facts
- chemical formula
- C₂₅H₃₂N₂O₂
- canonical SMILES
- CC(CN1CCOCC1)C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N4CCCC4
- Commons category
- Dextromoramide
- isomeric SMILES
- C[C@H](CN1CCOCC1)C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N4CCCC4
- World Health Organisation international non-proprietary name
- dextromoramide
- MCN code
- 2934.91.23
- defined daily dose
- 40
Sources (3)
via Wikidata · CC0
~5 min read
Article
6 sectionsContents
- History
- Medical use
- Pharmacokinetics
- Chemistry
- References
- Further reading
Dextromoramide (Palfium, Palphium, Jetrium, Dimorlin) is a powerful opioid analgesic approximately three times more potent than morphine but shorter acting. It is subject to drug prohibition regimes, both internationally through UN treaties and by the criminal law of individual nations, and is usually prescribed only in the Netherlands.
==History== Dextromoramide was discovered and patented in 1956 by Paul Janssen at Janssen Pharmaceuticals, who also discovered fentanyl, another important synthetic opioid, widely used to treat pain and in combination with other drugs as an anaesthetic, as well as haloperidol, piritramide, the loperamide-diphenoxylate series and other important drugs.