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GeneQ18033783· pop 6· linked from 9 articles

DOK2

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Also known as p56DOK, p56dok-2, docking protein 2

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.

Gene data

DOK2

Name: docking protein 2
Type: protein-coding
Position: 21,908,873–21,913,960 (−)
Aliases: p56DOK, p56dok-2
Ensembl: ENSG00000147443
RefSeq RNA: NM_001317800.2, NM_001401272.1, NM_003974.4, NM_201349.3
RefSeq protein: NP_001304729.1, NP_001388201.1, NP_003965.2, NP_958728.1

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

signal transduction cell surface receptor signaling pathway cell surface receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway Ras protein signal transduction

Molecular function

transmembrane receptor protein tyrosine kinase adaptor activity transmembrane receptor protein tyrosine kinase adaptor activity protein binding

Cellular component

cytoplasm cytosol plasma membrane

Pathways

Hemostasis Developmental Biology Cell surface interactions at the vascular wall Tie2 Signaling Axon guidance RET signaling Nervous system development RAC1-PAK1-p38-MMP2 Pathway IL-4 signaling pathway EGF-EGFR signaling pathway

via MyGene.info

Gene · Ensembl

docking protein 2

Symbol: DOK2
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:21,907,461-21,913,960
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein DOK2 PDB 2d9w.png

Show 5 more facts

HomoloGene ID: 2957
exact match: identifiers.org/ncbigene/9046
genomic end: 21913690
genomic start: 21766384
cytogenetic location: 8p21.3

Sources (3)

via Wikidata · CC0

~1 min read

Article

4 sections

Contents

Function
Interactions
References
Further reading

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.

== Function ==

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via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 8