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GeneQ2035393· pop 13· linked from 817 articles

DRD1

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Also known as dopamine receptor D1, DADR, DRD1A

protein-coding gene in the species Homo sapiens

Gene data

DRD1

Name: dopamine receptor D1
Type: protein-coding
Position: 175,440,027–175,444,794 (−)
Aliases: D1R, DADR, DRD1A
Ensembl: ENSG00000184845
RefSeq RNA: NM_000794.5
RefSeq protein: NP_000785.1

This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

synaptic transmission, dopaminergic G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway G protein-coupled dopamine receptor signaling pathway

Molecular function

dopamine neurotransmitter receptor activity, coupled via Gs dopamine neurotransmitter receptor activity, coupled via Gs dopamine neurotransmitter receptor activity, coupled via Gs dopamine neurotransmitter receptor activity, coupled via Gs G-protein alpha-subunit binding G protein-coupled receptor activity G protein-coupled receptor activity dopamine neurotransmitter receptor activity

Cellular component

nucleus endoplasmic reticulum endoplasmic reticulum membrane plasma membrane plasma membrane plasma membrane plasma membrane plasma membrane

Pathways

Calcium signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Gap junction - Homo sapiens (human)Dopaminergic synapse - Homo sapiens (human)Parkinson disease - Homo sapiens (human)Cocaine addiction - Homo sapiens (human)Amphetamine addiction - Homo sapiens (human)Morphine addiction - Homo sapiens (human)Alcoholism - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

dopamine receptor D1

Symbol: DRD1
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:175,440,027-175,444,794
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 6 more facts

HomoloGene ID: 30992
exact match: identifiers.org/ncbigene/1812
cytogenetic location: 5q35.2
genomic end: 175444182
genomic start: 175440036
Commons category: DRD1

Sources (6)

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Categories

Dopamine receptors Genes on human chromosome 5