halothaan

Also known as 2-bromo-2-chloro-1,1,1-trifluoroethane, 2,2,2-trifluoro-1-chloro-1-bromoethane, 1-bromo-1-chloro-2,2,2-trifluoroethane, 1,1,1-trifluoro-2-chloro-2-bromoethane, 1,1,1-trifluoro-2-bromo-2-chloroethane, bromochlorotrifluoroethane

groep van stereo-isomeren

In the Vinony graph

Vinony's link graph records 2,738 inbound references to halothaan, and connects out to ginkgolide, picrotoxin and inhalational anaesthetic.

It sits within the topics 5-HT3 receptor positive allosteric modulators, ECHA InfoCard ID from Wikidata and GABAA receptor positive allosteric modulators.

Vinony links it to 42 Wikipedia language editions.

Key facts

Drug.verifiedrevid: 443852402
Drug.image: 2-bromo-2-chloro-1,1,1-trifluoroethane 200.svg
Drug.image_class: skin-invert-image
Drug.width: 120
Drug.image2: Halothane-3D-vdW.png
Drug.image_class2: bg-transparent
Drug.width2: 120
Drug.tradename: Fluothane, Somnothane, Rhodialothan
Drug.DailyMedID: Halothane
Drug.routes_of_administration: Inhalation
Drug.class: Volatile anesthetic
Drug.ATC_prefix: N01
Drug.ATC_suffix: AB01
Drug.legal_BR: C1
Drug.legal_US: Rx-only
Drug.metabolism: Hepatic (CYP2E1)
Drug.excretion: Kidney, respiratory
Drug.CAS_number: 151-67-7

via Wikipedia infobox

Chemical data

Formula: C2HBrClF3
Molecular weight: 197.38 g/mol
IUPAC name: 2-bromo-2-chloro-1,1,1-trifluoroethane
SMILES: C(C(F)(F)F)(Cl)Br
InChIKey: BCQZXOMGPXTTIC-UHFFFAOYSA-N
XLogP: 2.3
Polar surface area: 0 Å²
H-bond donors: 0
H-bond acceptors: 3
Formal charge: 0

via PubChem

Research

19,814 papers

Halothane hepatitis: what's new?Drugs · 1980
Halothane hepatitis. Current concepts.Postgraduate medicine · 1974
The halothane hepatitis that was not.British journal of anaesthesia · 2020
Halothane hepatitis: a model of immune mediated drug hepatotoxicity.Clinical science (London, England : 1979) · 1987
Halothane hepatitis and the anaesthesiologist.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 1984

via PubMed

Wikidata facts

Mass: 195.890224

Show 13 more facts

chemical formula: C₂HBrClF₃
melting point: -180
NIOSH Pocket Guide ID: 0310
density: 1.87
boiling point: 122
vapor pressure: 243
solubility: 0.3
ceiling exposure limit: 16.2
World Health Organisation international non-proprietary name: 氟烷
Commons category: Halothane
canonical SMILES: C(C(F)(F)F)(Cl)Br
MCN code: 2903.79.31
global warming potential: 50

Sources (10)

via Wikidata · CC0

Article · Nederlands

Halothaan, systematisch bekend als 2-broom-2-chloor-1,1,1-trifluorethaan, is een dampvormig anestheticum (narcosegas) dat gebruikt wordt voor algehele anesthesie. Momenteel is het gebruik in Nederland minimaal vanwege potentiële bijwerkingen zoals leverontsteking (hepatitis). Nieuwere dampen zoals isofluraan, desfluraan en sevofluraan hebben het gebruik van halothaan overgenomen. Halothaan hoort bij de gehalogeneerde koolwaterstoffen. Wereldwijd wordt halothaan door de lage prijs nog zeer veel gebruikt. De stof is opgenomen in de lijst van essentiële geneesmiddelen van de WHO.

Abstract from DBpedia / Wikipedia · CC BY-SA