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GeneQ14907239· pop 10· linked from 258 articles

IFNL1

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Also known as IL-29, IL29, interferon, lambda 1, interferon lambda 1

protein-coding gene in the species Homo sapiens

Gene data

IFNL1

Name: interferon lambda 1
Type: protein-coding
Position: 39,296,407–39,298,673 (+)
Aliases: IL-29, IL29
Ensembl: ENSG00000291872
RefSeq RNA: NM_172140.2
RefSeq protein: NP_742152.1

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of type 2 immune response cell surface receptor signaling pathway via JAK-STAT negative regulation of cell population proliferation negative regulation of interleukin-13 production negative regulation of interleukin-5 production positive regulation of type II interferon production type III interferon-mediated signaling pathway positive regulation of tyrosine phosphorylation of STAT protein

Molecular function

signaling receptor binding signaling receptor binding cytokine activity interleukin-28 receptor binding

Cellular component

extracellular region extracellular region extracellular region extracellular region interleukin-28 receptor complex

Pathways

Cytokine-cytokine receptor interaction - Homo sapiens (human)JAK-STAT signaling pathway - Homo sapiens (human)Cytokine Signaling in Immune system Immune System Signaling by Interleukins Other interleukin signaling Interleukin-20 family signaling Type III interferon signaling Overview of interferons-mediated signaling pathway

via MyGene.info

Gene · Ensembl

interferon lambda 1

Symbol: IFNL1
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:39,296,407-39,298,673
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein IL28RA PDB 3OG4.png

Show 5 more facts

HomoloGene ID: 131189
exact match: identifiers.org/ncbigene/282618
genomic end: 39789313
genomic start: 39296407
cytogenetic location: 19q13.2

Sources (4)

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Categories

Cytokines Genes on human chromosome 19 Immunology Interleukins