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GeneQ18035336· pop 7· linked from 11 articles

IRF9

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Also known as IRF-9, ISGF3, ISGF3G, p48, interferon regulatory factor 9

Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G.

Gene data

IRF9

Name: interferon regulatory factor 9
Type: protein-coding
Position: 24,161,101–24,168,043 (+)
Aliases: IRF-9, ISGF3, ISGF3G, p48
Ensembl: ENSG00000285048
RefSeq RNA: NM_001385400.1, NM_001385401.1, NM_001385402.1, NM_006084.5
RefSeq protein: NP_001372329.1, NP_001372330.1, NP_001372331.1, NP_006075.3

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Mutations in this gene result in Immunodeficiency 65. [provided by RefSeq, Jul 2020].

Gene Ontology

Biological process

immune system process regulation of DNA-templated transcription regulation of transcription by RNA polymerase II transcription by RNA polymerase II cell surface receptor signaling pathway positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol

Pathways

Necroptosis - Homo sapiens (human)Osteoclast differentiation - Homo sapiens (human)NOD-like receptor signaling pathway - Homo sapiens (human)C-type lectin receptor signaling pathway - Homo sapiens (human)JAK-STAT signaling pathway - Homo sapiens (human)Hepatitis C - Homo sapiens (human)Measles - Homo sapiens (human)Influenza A - Homo sapiens (human)Human papillomavirus infection - Homo sapiens (human)Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

interferon regulatory factor 9

Symbol: IRF9
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:24,161,101-24,168,043
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 4436
exact match: identifiers.org/ncbigene/10379
genomic start: 24161265
genomic end: 24636611
cytogenetic location: 14q12

Sources (3)

via Wikidata · CC0

~1 min read

Article

4 sections

Contents

Interactions
References
Further reading
External links

Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G.

==Interactions== IRF9 has been shown to interact with STAT2 and STAT1.

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via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 14 Transcription factors