STAT1

Also known as CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1

Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family.

Gene data

STAT1

Name: signal transducer and activator of transcription 1
Type: protein-coding
Position: 190,908,460–191,020,960 (−)
Aliases: CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
Ensembl: ENSG00000115415
RefSeq RNA: NM_001384880.1, NM_001384881.1, NM_001384882.1, NM_001384883.1, NM_001384884.1
RefSeq protein: NP_001371809.1, NP_001371810.1, NP_001371811.1, NP_001371812.1, NP_001371813.1

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of endothelial cell proliferation positive regulation of mesenchymal cell proliferation positive regulation of defense response to virus by host positive regulation of defense response to virus by host negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis regulation of DNA-templated transcription regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific

Cellular component

chromatin chromatin nucleus nucleus nucleus nucleus nucleus nucleus

Pathways

via MyGene.info

Gene · Ensembl

signal transducer and activator of transcription 1

Symbol: STAT1
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:190,908,460-191,020,960
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Stat1 stucture.png

Show 5 more facts

HomoloGene ID: 21428
exact match: identifiers.org/ncbigene/6772
genomic end: 191885686
genomic start: 190908460
cytogenetic location: 2q32.2

Sources (7)

via Wikidata · CC0

~8 min read

Article

8 sections

Contents

Function
Mutations of STAT1
Loss of function
Gain of function
Interactions
References
Further reading
External links

Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family.

== Function == All STAT molecules are phosphorylated by receptor associated kinases, that causes activation, dimerization by forming homo- or heterodimers and finally translocate to nucleus to work as transcription factors. Specifically STAT1 can be activated by several ligands such as Interferon alpha (IFNα), Interferon gamma (IFNγ), Epidermal Growth Factor (EGF), Platelet Derived Growth Factor (PDGF), Interleukin 6 (IL-6), or IL-27.