RSF1

Also known as HBXAP, RSF-1, XAP8, p325, remodeling and spacing factor 1

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.

Gene data

RSF1

Name: remodeling and spacing factor 1
Type: protein-coding
Position: 77,660,009–77,820,869 (−)
Aliases: HBXAP, RSF-1, XAP8, p325
Ensembl: ENSG00000048649
RefSeq RNA: NM_016578.4, XM_005274051.3, XM_017017923.2, XM_054369127.1, XM_054369128.1
RefSeq protein: NP_057662.3, XP_005274108.1, XP_016873412.1, XP_054225102.1, XP_054225103.1

This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011].

Gene Ontology

Biological process

chromatin organization

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Article

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Contents

References
Further reading

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.

HBXAP is involved in transcription repression, transcription coactivation when associated with hepatitis B virus X protein (HBX), and chromatin remodeling and spacing when associated with SNF2H (MIM 603375).[supplied by OMIM]